MSM capsules

MSM (methylsulfonylmethane) is identical in both forms. Capsules offer convenience and a precise dose — ideal for doses of 500 mg to 2 g per day (maintenance or gradual introduction). Flakes (crystallised flakes) are more economical and allow higher, easily flexible doses — recommended for the therapeutic doses of 3 to 6 g/day used in clinical joint studies. For high joint doses, flakes are more practical.

Follow the Kiki Health packaging recommendations. Clinical joint studies use doses of 1,500 to 6,000 mg/day. If each capsule contains 500 mg, this represents 3 to 12 capsules per day depending on your objective. To start, 1 to 2 capsules (500 to 1,000 mg) is sufficient, with gradual increase over 2 to 4 weeks. Take with a large glass of water, preferably with a meal to avoid the mild nausea sometimes observed on an empty stomach.

Randomised controlled clinical trials show that MSM at doses of 1,500 to 3,000 mg/day for 12 weeks significantly reduces pain and improves joint function in knee osteoarthritis (Kim 2006, Osteoarthritis and Cartilage). Its anti-inflammatory mechanism involves inhibition of NF-kB and reduction of pro-inflammatory cytokines. MSM also provides sulphur indispensable for glycosaminoglycan synthesis, a structural component of cartilage.

Yes, the combination MSM + glucosamine + chondroitin is one of the most studied for joint health. A 2007 study in Osteoarthritis and Cartilage compared glucosamine alone vs glucosamine + MSM vs placebo — the combination was superior to glucosamine alone for reducing pain and improving mobility. Also combine with hydrolysed collagen and omega-3 for a complete joint protocol.

MSM itself is an organic synthetic molecule with no food allergens. However, people sensitive to sulphur or sulphites should be vigilant (although MSM is organic sulphur chemically different from inorganic sulphites). Check the Kiki Health packaging for allergen mentions related to capsule excipients (bovine gelatine vs vegetable HPMC, filling agents).

Studies on athletes show that MSM reduces post-exercise oxidative stress markers (isoprostanes, oxidised glutathione) and muscle damage (creatine kinase). A 2012 study in the Journal of the International Society of Sports Nutrition showed that 50 mg/kg of MSM for 10 days reduced delayed onset muscle soreness (DOMS) and improved muscle recovery in healthy men versus placebo.

MSM is generally very well tolerated. Contraindications: known allergy to sulphur or sulphites (precaution); people on anticoagulants (potential additive interaction); proven renal insufficiency (consult your doctor); pregnancy and breastfeeding (insufficient data). Children should not use this product without medical advice.

SuperKure is the official distributor of Kiki Health in France. Order at superkure.fr with 24–48h delivery from our French warehouse. No customs fees, free delivery from €60. For an optimal joint protocol, combine Kiki Health MSM Capsules with the Marine Collagen and Omega-3 available at superkure.fr.